San Francisco 49ers running back Christian McCaffrey became the fifth running back in NFL history, joining three Hall of Famers, to hit new milestone.

The Tennessee Titans reportedly have three players available for trade and that could lead to deadline deals with the San Francisco 49ers, Detroit Lions and Los Angeles Rams.

Here is how the 49ers (5-3) graded in Sunday’s 26-15 loss to the host (3-4): PASS OFFENSE: F. Third-down failures on the first three series set the to

Purdy was on the 49ers’ sideline in a road game for the first time since re-aggravating his toe injury against the Jaguars. He did not travel to Los Angeles on Oct. 2, and didn't travel to Tampa on Oct. 11. While he was on the sideline for last week’s game against Atlanta, that was a home game.

The 49ers offense sabotaged the defense and the defense failed to set up the offense in one-sided loss to Texans.

Down 16-0, the 49ers came alive with last-minute theatrics before halftime, highlighted by Kittle’s 17-yard, third-down touchdown catch. Setting up that score was Brian Robinson’s 46-yard kick return – the 49ers’ longest this season – plus a 15-yard facemask penalty, followed by an 18-yard catch from Kendrick Bourne.

Kickoff from NRG Stadium is set for 1 p.m. ET, and the Texans are 2.5-point favorites, according to the latest 49ers vs. Texans odds. The over/under for total points scored is 42. The Texans are -151 money line favorites (risk $151 to win $100),

Highlights from the Week 8 matchup between the San Francisco 49ers and the Houston Texans during the 2025 NFL season.

Hunter had a statement day for himself in the process of the Texans' Week 8 victory. The veteran edge rusher logged his fourth sack of the year in the fourth quarter of the game on Jones to secure Houston's third win of the season, and effectively keep them just one game under .500 entering the halfway point of the new year.

The Texans have dominated the 49ers, outgaining them 230 to 25 and outscoring them 13-0. The Texans have 10 first downs to none for the 49ers, who had only four plays in the first quarter with Christian McCaffrey getting no touches.