Mitochondrial dysfunction and endoplasmic reticulum (ER) stress are considered the key determinants of insulin resistance. Impaired mitochondrial function in obese animals was shown to induce the ER ...
For decades, scientists understood inducible nitric oxide synthase, or iNOS, as a one-trick enzyme. Its job was to churn out ...
Researchers have shown that a protein-protein interaction between iNOS and IRG1 is crucial for regulating inflammation. The ...