In the classical model of G-protein-coupled receptor (GPCR) regulation, arrestin proteins terminate receptor signalling. After receptor activation, arrestins desensitize GPCRs by binding to ...
G protein-coupled receptors (GPCRs) are essential for cell signal transduction and constitute the largest drug target protein family. Upon agonist stimulation, these receptors activate multiple ...
Researchers have been studying two proteins that play a vital role in many bodily processes. Results identify a previously unknown binding element critical to the arrestin -- GPCR interaction.
The existence of this type of interaction was previously unknown, and its discovery opens up a whole new field of research regarding how the membrane influences the function of arrestin. A better ...
The protein β-arrestin-2 increases the accumulation of neurotoxic tau tangles, a cause several forms of dementia, by interfering with removal of excess tau from the brain, a new study by the ...
Recent years have seen major advances in understanding the structure-function relationships of G protein-coupled receptors (GPCRs). This large superfamily of transmembrane receptors comprises over 800 ...
Researchers from Charité - Universitätsmedizin Berlin have been studying two proteins that play a vital role in many bodily processes. The aim of the research was to establish how G-protein-coupled ...
Researchers have found that the level of a single protein in the tiny roundworm C. elegans determines how long it lives. Worms born without this protein, called arrestin, lived about one-third longer ...
Researchers from Charité - Universitätsmedizin Berlin have been studying two proteins that play a vital role in many bodily processes. The aim of the research was to establish how G-protein-coupled ...
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