FAK (focal adhesion kinase) is widely involved in cancer growth and drug resistance development. Thus, FAK inhibition has emerged as an effective strategy for tumor treatment both as a monotherapy or ...
Acute lymphoblastic leukemia (ALL) is a genetically heterogeneous malignancy often associated with poor prognosis due to chemotherapy resistance and relapse. Histone deacetylase (HDAC) inhibitors ...
Graphical illustration depicting the multifaceted role of FAK in cancer. FAK is activated by integrins, RTKs, and GPCRs, driving downstream oncogenic processes including proliferation, EMT/invasion, ...
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