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Ursodeoxycholic acid for the management of drug-induced liver injury: Role of hepatoprotective and anti-cholestatic mechanisms

Drug-induced liver injury (DILI) is a harmful reaction to medications, herbs, and dietary supplements that results in liver dysfunction. Based on the distinct clinical patterns of liver damage, DILI ...
Nature

Ursodeoxycholic acid protects interstitial Cajal-like cells in the gallbladder from undergoing apoptosis by inhibiting TNF-α expression

Gallstones are mainly composed of cholesterol or pigments, and only patients with symptoms or complications are considered to have gallstone disease from a clinical perspective. These symptoms include ...
Healio

Ursodeoxycholic acid fails to reduce fetal risk in intrahepatic cholestasis of pregnancy

Please provide your email address to receive an email when new articles are posted on . Ursodeoxycholic acid did not reduce complications with intrahepatic cholestasis of pregnancy. Its use was linked ...
EurekAlert!

Ursodeoxycholic acid shows unexpected gut FXR agonism in liver FXR-deficient mice

(A) Female and male body weight change over the course of 16 weeks for FXR hep flox/flox and FXR hep-/- (B) Female and male liver-to-body weight ratios; (C) H&E stained liver sections (n=3–6); (D) ...