A protein that regulates mRNA decoding can itself be regulated with implications for understanding cancer

Decoding of messenger RNA (mRNA) occurs during translation, the vital cellular process that builds proteins. Errors in this ...
BIOENGINEER

Methylated translation factor speeds decoding of rare codons to drive cancer growth

A methylation mark on translation factor eEF1A selectively speeds decoding of rare, wobble-weak codons, boosting KRAS ...
Tech Times on MSN

KRAS drug resistance has upstream cause: METTL13 enzyme fuels tumor protein overload

KRAS cancer treatment may have a new upstream target: the METTL13 enzyme that helps tumors overproduce KRAS protein and ...
BIOENGINEER

Scientists reveal how a methyl tag on eEF1A speeds KRAS translation and fuels cancer drug resistance

St. Jude scientists showed that METTL13-driven methylation of the translation factor eEF1A selectively speeds decoding of ...
Phys.org

How an RNA-binding protein detects and responds to non-optimal codon usage in human cells

Human genes are written in long strings of three-letter units composed of four different nucleotides. These units—or codons—specify one of many amino acids, the building blocks of proteins. Multiple ...
News Medical

Expanding the genetic code in mammalian cells using pseudouridine modified codons

To overcome the inherent challenge of translation termination interference caused by stop codon reprogramming in mammalian cells, researchers from Peking University led by Chen Peng from College of ...
Nature

Translation: DNA to mRNA to Protein

How does the cell convert DNA into working proteins? The process of translation can be seen as the decoding of instructions for making proteins, involving mRNA in transcription as well as tRNA. But ...