Each time he would be revived and “evolved,” then killed again. While Bertron, who created Doomsday in the comics, is replaced by a Zod and an El, the basics of the origin remain untouched.
At least one Avenger is definitely not going to be showing up for Avengers: Doomsday, despite their key role in past films.
This is an arc that lasts far longer in the comics, and Avengers: Doomsday might be a good time ... with Tom Cruise's near-miss being among the most eyebrow-raising. Long before the MCU was ...