Death certificate data indicate that hypertension may have increased as a contributing cause of death among US adults. Hypertension is not commonly recorded on death certificates although it ...

VESALIUS-CV is a large (N=12 257), rigorously conducted, international, randomized, placebo-controlled trial conducted in patients at high cardiovascular risk but without prior myocardial infarction ...

eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are ...

Little DT, Howard CM, Pendergraft E, Brittian KR, Audam TN, Lukudu EW, Smith J, Nguyen D, Nishida Y, Yamaguchi Y, et al. Activated cardiac fibroblasts are a primary source of high-molecular-weight ...

Circulation: Population Health and Outcomes, a journal of the American Heart Association, invites applications for an Associate Editor to join the journal’s new editorial team led by incoming ...

BACKGROUND: Peripheral artery disease (PAD) and its severe form, chronic limb-threatening ischemia (CLTI), significantly impair blood flow to the lower extremities, affecting millions of adults ...

The arterial vasculature is the second most frequently calcified structure in the human body after the skeleton. Calcification of the aorta and aortic valves occurs in most individuals in westernized ...

BACKGROUND: Aortic valve calcification increases leaflet stiffness and contributes to the development of calcific aortic valve disease. The molecular and cellular mechanisms underlying calcification ...

BACKGROUND: Consensus-based clinical practice guidelines recommend echocardiographic surveillance intervals based on aortic stenosis (AS) severity; however, real-world surveillance practices and ...

Atherosclerotic cardiovascular disease (ASCVD) is a leading cause of morbidity and mortality globally. Low-density lipoprotein cholesterol is a causal risk factor for atherosclerotic cardiovascular ...

BACKGROUND: There is limited evidence of the relationship between aortic and iliac calcification and aortic events (aortic dissection or aneurysm rupture) and major adverse limb events (MALEs; ...